Lee, Jong-Eun
Title: Professor
Affiliation: Department of Biology, Chonnam National University
Degree:Ph.D. Chonnam National University, Korea
Address: Department of Physiology Chonnam University Medical School 5 Hak-dong, Kwangju 501-190
Tel.:+82-62-220-4262
FAX:+82-62-220-4262
Email:julee@orion.chonnam.ac.kr

   The blood pressure-regulating mechanisms are subjected to both neural and endocrine regulation as with other bodily functions. Our laboratory has been interested in the endocrine control of the blood pressure, and focused on altered roles of renin-angiotensin, nitric oxide, and atrial natriuretic peptide systems in the development and maintenance of hypertension. Circulating levels of these hormones are measured, and components of these hormonal systems are determined at molecular levels using Northern blot, Western blot and PCR techniques. The results indicate that an attenuation of the nitric oxide system and an enhancement of the various components of renin-angiotensin system substantially contribute to the development and maintenance of high blood pressure in several models of hypertensive animals.

  1. Kim SW, Moon KH, Lee SC, Kim NH, Kang DG, Lee J, Choi KC, Kang YJ (1999) Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats. Kor J Int Med 14: 21-26
  2. 김인광, 강대길, 이종은, 오봉석 (1999) Altered vascular expression of nitric oxide synthase isozymes in hypertension. 대한흉부외과학회지. 32: 138-143
  3. Lee J, An MR (1999) Tissue-specific regulation of angiotensinogen and angiotensin II receptor gene expression in deoxycorticosterone acetate-salt hypertensive rats. Korean J Physiol Pharamacol 3: 315-320
  4. Nam SC, Jeong HJ, Kim W, Lee J (1999) Altered calcium current of the vascular smooth muscle in renal hypertension. Korean J Physiol Pharamacol 3: 351-356
  5. Lee J, Kang DG, Kook H, Kim IK, Oh BS (1999) Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats. J Korean Med Sci 14: 386-392
  6. 이종은, 김수완, 유광재, 최기철 (1999) 혈관 내피층 호르몬 (종설). 전남의대잡지. 35: 135-163
  7. 김남호, 정권, 김수완, 정영도, 이기영, 안봉환, 이종은, 최기철, 강영준 (1999) 혈액투석 중에 발생하는 저혈압에서 산화질소의 역할. 전남의대잡지. 35: 221-230
  8. Welch WJ, Tojo A, Lee J, Kang DG, Schnackenberg CG, Wilcox CS (1999) Nitric oxide synthase in the JGA and role in tubuloglomerular feedback. Am J Physiol 277: F130-F138
  9. Jang AS, Choi IS, Lee S, Seo JP, Yang SW, Park KO, Lee KY, Lee JU, Park CS, Park HS (1999) Nitric oxide metabolites in induced sputum: a marker of airway inflammation in asthmatic subjects. Clin Exp Allergy 29: 1136-1142
  10. 허성윤, 이종은 (1999) 흰쥐에서 Cyclosporine에 의한 혈관 내피층 기능 변화. 대한신장학회지. 18: 683-691
  11. An MR, Chung YJ, Kang DG, Nam SC, Lee J (1999) Augmented expression of cardiac atrial natriuretic peptide system in hypertensive rats. J Korean Med Sci 14: 497-501
  12. Lee J, Kim SW, Kook H, Kang DG, Kim NH, Choi KC (1999) Effects of L-arginine on cyclosporine-induced alterations of vascular NO/cGMP generation Nephrol Dail Transplant 14: 2634-2638
  13. Yoo KY, Yang SY, Lee J, Im WM, Jeong CY, Chung SS, Kwak SH (1999) Intracoronary propofol attenuates myocardial but not coronary endothelial dysfunction after brief ischemia and reperfusion in dogs. Brit J Anaes 82
  14. Yang ES, Lee J, Kang DG (1998) Altered renal nitric oxide system in experimental hypertensive rats. Kor J Physiol Pharmacol 2: 455-460
  15. Yeum C-H, Yang M-J, Jun J-Y, Yoon P-J, Moon S-H, Kim J-H, Lee J (1998) Effects of nitric oxide synthesis inhibition on the blood pressure response to bradykinin in rats. 대한신장학회지 17: 667-672
  16. Kim JS, An MR, Kim NH, Choi KC, Lee J (1998) Effects of cyclosporine on the intrarenal renin-angiotensin system. 대한신장학회지 17: 679-685
  17. 차민정, 안미라, 이종은 (1998) Long-term effects of pentobarbital on atrial natriuretic peptide system in rats. 대한마취과학회지 35: S8-S14
  18. 김인광, 강대길, 이종은, 오봉석 (1998) Altered vascular expression of nitric oxide synthase isozymes in hypertension. 대한흉부외과학회지 32: 203-207
  19. 문승호, 이종은, 유광재, 오봉석, 이동준 (1998) L-Arginine의 산화질소생성과 무관한 혈관이완효과 대한흉부외과학회지 31: 102-107
  20. Choi KC, Jung M, Lee J, Kim SW, Kim NH, Kang YJ (1997) Attenuated central pressor response to nitric oxide synthesis inhibition in chronic renal failure rats. Korean J Int Med 12: 58-61
  21. Oh HS, Yoo K, Kim M, Choi KC, Lee J (1997) Changes of the plasma endothelin in adaptation to increased salt intake in rats. Korean J Int Med 12: 62-66
  22. Kim SW, Lee J, Kim NH, Choi KC (1997) Effects of altered body fluid balance and high blood pressure on the plasma brain natriuretic peptide in rats. J Kor Med Sci 12: 117-122
  23. Choi EH, Kim M, Lee J (1997) Regulatory role of nitric oxide on atrial natriuretic peptide system in normotensive and hypertensive rats. Korean J Physiol Pharmacol 1: 79-82
  24. Choi KC, Kim NH, An MR, Kang DG, Kim SW, Lee J (1997) Alterations of intrarenal renin-angiotensin and nitric oxide system in streptozotocin-induced diabetic rats. Kidney Int 52: S-23-S-27
  25. Kim W, Lee J, Park YH, Nam SC (1997) Altered vascular calcium regulation in hypertension. Kor J Physiol Pharmacol 1: 529-535
  26. 나국주, 이종은 (1996) 신혈관성 고혈압 흰쥐에서 혈장 Renin의 기원. 대한신장학회지 15: 142-148
  27. Lee J, Park KK, Choi KC, Yoo K, Kim W, Lee K-Y, Kook H, Kim SW, Kim NH, Baik YH (1996) L-Arginine restores cyclosporine-induced impairment of vascular relaxation and cGMP generation. 대한신장학회지 15: 149-155
  28. Ahn HT, Nah KJ, Lee J (1996) Interrelation between renin-angiotensin and endothelium-derived nitric oxide systems in two-kidney, one clip hypertensive rats. Kor J Physiol 30: 33-41
  29. Lee J (1996) Role of prostaglandins in the stimulated-release of natriruetic peptides and endothelin. Chonnam J Med Sci 9: 8-12
  30. Baik YH, Kim Y, Kook H, Lee J (1996) Changes in tension and tissue cGMP content of porcine cerebral artery in response to hypoxia. Chonnam J Med Sci 9: 55-61
  31. 이종은, 김수완, 김남호, 최기철 (1996) 신장과 산화질소. 대한신장학회지 15(부록2): S55-S70
  32. 최기철, 이제중, 김수완, 이종은 (1996) 만성신부전 흰쥐에서 혈압조절에 미치는 nitric oxide계의 기능변화. 대한신장학회지
  33. Lee J, Choi KC, Yeum CH, Kim W, Yoo K, Park JW, Yoon PJ (1995) Impairment of endothelium-dependent vasorelaxation in chronic two-kidney, one clip hypertensive rats. Nephrol Dial Transplant 10: 619-623
  34. 박광성, 김은영, 이종은, 류수방 (1995) 내피의존이완인자와 과분극인자의 음경해면체 이완효과. 대한비뇨기과학회지 36: 241-246
  35. 이종은, 유광재: Endothelin (1995) 고혈압과 혈관비후의 원인인가? 순환기 25(부록5): 49-53
  36. 이석기, 최형호, 이종은 (1995) 토끼 흉부 대동맥 절편의 전기자극에 대한 수축 및 이완반응. 대한흉부외과학회지 28: 742-746
  37. Lee J, Lim SC, Jeong HS, Choi KC, Oh BS, Park SS (1994) Long-term effects of pentobarbital anesthesia on the atrial natriuretic peptide system in rats. Proc Soc Exp Biol Med 205:62-66
  38. Choi KC, Park HC, Lee J (1994) Attenuated release of atrial natriuretic peptide and vasorelaxation in streptozotocin-induced diabetic rats. Korean J Med Sci 9:101-106
  39. Kim W, Kook H, Lee J, Yoo K, Choi KC and Baik YH (1994) L-Arginine prevents the impairment of vascular cGMP generation in diabetic rats. Chonnam J Med Sci 7:18-21
  40. Moon SH, Yang MJ, Oh SH, Kim M, Yoo K, Lee J, Jun JY, Yeum CH and Yoon PJ (1994) A central pressor response to endogenous nitric oxide synthesis inhibition in anesthetized rats. Kor J Physiol 28: 197-202
  41. Lee J, Kim DH, Kim YJ, Kim W, Yoo K, Choi KC and Lee J (1994) Role of endogenous nitric oxide in the control of renin release. Kor J Physiol 28: 225-231
  42. Choi KC, Lee J, Moon KH, Park KK, Kim SW, Kim NH (1993) Chronic caffeine ingestion exacerbates 2-kidney, 1-clip hypertension and ameliorates deoxycorticosterone acetate-salt hypertension in rats. Nephron 65:619-622
  43. Lee J, Koh CS, Yeum CH (1993) Both nifedipine and Bay K 8644 potentiate the release of atrial natriuretic peptide in response to volume expansion. Korean J Physiol 27:51-55
  44. Choi KC, Lee J, Kim SW, Kim NH, Moon KH, Park KK, Bom HS, Kang YJ (1993) Cimetidine improves the accuracy of creatinine clearance as an indicator for glomerular filtration rate. Korean J Int Med 8:28-34
  45. Lee J, Jeong MJ (1993) Carbohydrate moiety contributes to the heterogeneity and stability of renin. Chonnam J Med Sci 6:27-30
  46. 정혜전, 조경행, 이종은 (1993) 흰쥐에서 Pentobarbital이 Atrial Natriuretic Peptide 분비반응성에 미치는 효과. 대한마취과학회지 26:627-632
  47. 이종은, 유광재, 최기철 (1993) 신장에서 일산화질소(Nitric Oxide)의 역할. 대한신장학회지 12: S75-S82
  48. 김영재, 오필석, 신숙, 강정채, 이종은 (1993) 흰쥐에서 Endothelin 승압효과에 미치는 Atrial Natriuretic Peptide와 NaCl의 영향. 순환기 23:590-596
  49. Choi KC, Uhm SH, Park SM, Lee J, Kang YJ (1993) Endogenous nitric oxide mediates the renal response to amino acid infusion. Korean J Nephrol 12:505-511
  50. 박광성, 이종은, 류수방 (1993) 토끼 음경해면체 평활근 이완에 Nitric Oxide와 Vasoactive Intestinal Peptide의 역할. 대한남성과학회지 11:55-61