Kang, Hae-Mook
Title: Assistant Professor
Affiliation:Dept. Genetic Engineering, Chongju University
Degree:Ph.D. Seoul National University, Korea
Address:Dept. Genetic Engineering, Chongju University,
Chongju 360-764, Korea
Tel.:+82-431-229-8565
FAX:+82-431-229-8432
Email:hmkang@alpha94.chongju.ac.kr

Present main research activities are followed.
I am interesting the intracellular signaling mechanism during meiotic resumption in frog oocyte (Rana dybowskii). To reveal this mechanism at molecular level, I have focused on the regulation of MPF activity and other kinase activity during progesterone-stimulated and sponatenous oocyte maturation. Perhaps, this work will give a new insight on the understading of regulatory mechanism of oocyte maturation.
I have also focused to cloning and characterization of cDNAs encoding steroidogenic enzymes in frog (Rana species). This work will ultimately be elucidated the mechanism of steroidogenic shift occurred during follicle growth and the control mechanism of the plasma progesterone level involved in the meiotic resumption of oocyte maturation in amphibia.

  1. J. Bandyopadhyay, A. Bandyopadhyay, H.-S. Choi, H. B. Kwon, and H. M. Kang (1999) Cloning and characterization of cDNA encoding Cdc2 kinase, a component of maturation promoting factor, in Rana dybowskii. Gen. Comp. Endocrinol. (accepted)
  2. S.K. Ko, W.B. Im, H.M. Kang, and H.B. Kwon (1998) Seasonal changes in testicular reproduction cycle in Korean three species of native frogs, Rana dybowskii, Rana rugosa and Rana nigromaculata. Gen. Comp. Endo. (in press)
  3. Choi, H.H., H.M. Kang, H.S. Choi, and H.B. Kwon. Cloning and characterization of cDNA encoding 17ес-hydroxylase/17,20-lyase (P450C17) in ovary of frog (Rana dybowskii). (in preparation)
  4. M.S. Yoo, H.M. Kang, H.S. Choi, K. Kim and H.B. Kwon. The complete nucleotide sequence and deduced amino acid of gonadotropin-releasing hormone in bullfrog (Rana catesbeiana) (in preparation)
  5. Bandyopadhyay, J., A. Bandyopadhyay, H.S. Choi, H.B. Kwon, and H.M. Kang. cdc2 kinase as a component of MPF in Rana dybowskii. (in preparation)
  6. Ko, S. K., Kang, H. M., Im, W. B., and H. B. Kwon. (1998) Testicular cycles in three species of Korean frogs: Rana nigromaculata, Rana rugosa, and Rana dybowskii. Gen. Comp. Endo. 111:347-358
  7. Lee, S.J., W.L. Kim, H.S. Kang, C.K. Lee, B.J. Lee, H.M. Kang, and S.G. Kang (1998) Studies on the regulation of ovarian granulosa cell apoptosis by gonadotropons and nitric oxide. Dev. Reprod. 1:157-164
  8. Kim, W.L., S.J. Lee, H.S. Kang, C.K. Lee, B.J. Lee, H.M. Kang, and S.G. Kang. (1998) Gonadotropins and nitric oxide can suppress the expression of mouse follicular bad and bax genes. Dev. Reprod. 1:165-172
  9. Lee, C.K., H.S. Kang, B.J. Lee, H.M. Kang, and S.G. Kang (1998) Effects of dopamine and estrogen on the regulation of Pit-1ес, and Pit-1ет and PL-II gene expression in the rat placenta. Mol. Cells. 8:205-211
  10. Bandyopadhyay, J., A. Bandyopadhyay, H.M. Kang, H.B. Kwon, and H.S. Choi (1998) Requirment of protein kinase C pathway during progesterone-induced oocyte maturation in amphibian, Rana dybowskii. Korean J. Biol. Sci. 2:93-98
  11. Jang, K.J., J.W. Kim, W.-B. Im, H.M. Kang, and H.B. Kwon (1997) Differential effect of gonadotropin and orthovanate on oocyte maturation, ovulation and prostaglandin synthesis by Rana ovarian follicles in vitro. J. Exp. Zool. 277:155-165.
  12. S.K. Ko, H.M. Kang, J.W. Kim, and H.B. Kwon (1997) Testicular cycles in the Korean frogs: Annual spermatogenic patterns, seasonal changes in the steroidogenic competence, and responsiveness to gondotropins in vitro. Korean J. Biol. Sci. 1:99-105.
  13. Kang, H.M., N.K. Kang and H.S. Shin (1997) Insertional mutagenesis by using a dicistronic gene-trap vector in mouse. Mol. Cells. 7:502-507.
  14. J.K. Jeong, S.G. Kang, H.M. Kang, and B.J. Lee (1996) Effect of estrogen on the gestational profiles in gene expression of placental lactogen I, II and Pit-1 in the rat placenta. Korean J. Zoology. 39:115-121.
  15. B.J. Lee, J.H. Kim, C.K. Lee, H.M. Kang, H.C. Kim, and S.G. Kang (1995) Changes in mRNA levels of a pituitary-specific trans-acting factor, Pit-1 and prolactin during the rat estrous cycle. Eur. J. Endocrinology. 132:771-776.
  16. Jeong, S.J., H.M. Kang, S.G. Kang, and K. Kim (1995) Expression of c-myc proto-oncogene in preimplantation mouse embryo. Korean J. Zool. 38:196-203.
  17. K.S. Park, H.M. Kang, C.S. Shim, W. Sung, J. Kim, Y.K. Lee, and K. Kim (1995) Zygotic expression of c-myc gene in mouse early embryos : Functional role of c-myc promoter. Korean J. Zool. 38:550-556.
  18. Kang, H.M., B. St-Jacque, F. Schwartz and H.-S. Shin (1994) Gene targeting in the Ke-4 locus of the mouse embryonic stem cells. Mol. Cells. 4:27-32.
  19. Cho, B.N., J.Y. Seong, S. Cho, H.M. Kang, and K. Kim (1994) Progesterone inhibits luteinizing hormone ет-subunit gene expression in the rat pituitary in a synergic manner with estrogen. Korean J. Zool. 37:377-384.
  20. Lee, S.H., W.S. Choi, C. Kim, H.M. Kang, D. Geum, H.-S. Park, Y.M. Park, C.C. Lee, and K. Kim (1994) A local regulation of GnRH release and gene expression in rat granulosa cells by endogeneous opioid. Mol. Cells. 4:473-479.
  21. Kang, H.M., D.K. Lee, H.B. Kwon, C.C. Lee and K. Kim (1993) Functional role of maturation promoting factor in mouse two-cell embryos. Korean J. Zool. 36:276-284