Researchers

  Research Interest

The main interest is to investigate the mechanisms for hormonal regulation of inflammation and microbial infections. These include the cascade processes from platelet-activating factor release to cytokine expression through activation of the transcrition factor, NFkB

• Signal transduction and molecular mechanisms of inflammation and infections
• The biological role of NFkB activation in inflammation and microbial infections
• The role of NFkB in angiogenesis
• The mechanisms of hormone-induced angiogenesis

  Research Fellow

• Ko, Hyun-Mi (gusalrh@hanmail.net)
  - Post Doctor. Chonnam national university
  - Ph.D. in Biology, Chonnam national university
  - M.S. in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Mechanism of PAF-induced angiogenesis

• Han, Su-Ji (sujihan@hanmail.net)
  - Doctoral Course in Biology, Chonnam national university
  - M.S. in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Mechanisms for multiple activation of NF- B in inflammatory reaction.

• Choi, Jung-Hwa (cjunghwa@hanmail.net)
  - Doctoral Course in Biology, Chonnam national university
  - M.S. in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Role of PAF in Candida infection.

• Seo, Kook-Heon (seokh1205@hanmail.net)
  - Doctoral Course in Biology, Chonnam national university
  - M.S. in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Reciprocal regulation of NF- B and AP-1 in inflammatory reaction.

• Lee, Hyun-Suk (sys23@hanmail.net)
  - Master Course in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Role of PAF in estrogen-induced angiogenesis.

• Choi, Eun-Kyoung (cek7015@hanmail.net)
  - Master Course in Biology, Chonnam national university
  - B.S. in Microbiology, Chonnam national university
  - Mechanisms for no I Ba degradation in H2O2-induced NF- B activation

• Lee, Hyo-Jin (dhmate@hanmail.net)
  - Master Course in Biology, Chonnam national university
  - B.S. in Biological Science, Chonnam national university
  - Organ differences in NO expression in C. albicans infection

• Jung, Hea-Hyun (jhh2-2@hanmail.net)
  - Master Course in Biology, Chonnam national university
  - B.S. in Biological Science, Chonnam national university
  - Mechanisms for macrophage-induced angiogenesis

  Recent Publications

Choi JH, Ko HM, Kim JW, Lee HK, Han SS, Chon SB, and Im SY (2001) Platelet-activating factor-induced early activation of NF-kB plays a crucial role for organ clearance of Candida albicans.  J. Immunol. (in press, 2001 3/15)
 
Choi JH, Chung WJ, Han SJ, Lee HH, Im SY (2000) Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kB. Inflammation
 
C. Fenwick, S.-Y. Na, R.E. Voll, H. Zhong, S.Y. Im, J.W. Lee and S. Ghosh (2000) A sub-class of Ras proteins that regulate the degradation of IkB. Science, 287:869-873
 
Lee HJ, Shin DJ, Cho NC, Kim HO, Shin SY, Im SY, Lee HB, Chun SB, Bai S (2000) Cloning, expression and nucleotide sequence of two xylanase genes from Paenibacillus sp. Biotechnology Letters, 22:387-392
 
BY Kang, SW Chung, W-J Chung, S-Y im, SY Hwang and TS Kim (1999) Inhibitionof interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin. Eur J. Pharmacol., 384:191-195
 
BY Kang, SW Chung, S-Y Im, Y-K Choe, and TS Kim (1999) Sulfasalazine prevents Th1 immune response by suppresing IL-12 production in macrophages. Immunology. 98(1):98-103
 
SY Lee, S-Y Im, KM Kim (1999) Preparation of dopamine transporter-specific antibodies using molecular cloned genes. Arch. Pharm. Res. 22(3):262-266
 
BY Kang, SW Chung, S-Y Im, SY Hwang and TS Kim (1999) Chloromethyl ketones inhibit interleukin-12 production in macrophages stimulated with lipopolysaccharide. Immunol. Lett., 70:135-138
 
S.Y. Na, B.Y. Kang, S.W. Chung, S.W. Chung, S.J. Han, X. Ma, G. Trinchieri, S.Y. Im, J.W. Lee, T.S. Kim (1999) Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor NF kappa B. J. Biol. Chem. 274:7674-7680
 
Su Ji Han, Jung Hwa Choi, Hae Won Yang, Hyun Mi Ko, Il Whan Cho,. Hern-Ku Lee, Oh Hyoung Lee and Suhn-Young Im (1999) Glucocorticoids prevent NF-¥êB activation by inhibiting the early release of platelet-activating factor in response to LPS. Eur. J. Immunol. 29:1334-1341
 
Soon-Young Na, Soo-Kyung Lee, Su-Ji Han, Hueng-Sik Choi, Suhn-Young Im, Jae Woon Lee (1998) Steroid receptor coactivation-1 interacts with p50 subunet and coactivates nuclear factor kappaB-mediated transactivation. J. Biol. Chem., 273:10831-10834
 
Soo-Kyung Lee, Han-Jong Kim, Soon-Young Na, Tae-Sung Kim, Hueng-Sik Choi, Suhn-Young Im, Jae Woon Lee (1998) Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J. Biol. Chem., 273:16651-16654
 
Hee Young Chung, Min Hee Hong, Young Hyun Chun, Suk Bai, Suhn-Young Im, Hwanghee Blaise Lee, Jong Chun Park, Dong Ho Kim, and Soon-Bai Chun (1998) Nucleotide analysis of Phaffia rhodozyma DNA fragment that functions as ARS in Saccharomyces cerevisiae. J. Microbiol. Biotechnol., 8(6):650-655
 
Il Hwan Choi, Young Min Shin, Jae Seung Park, Moo Sam Lee, Eue Hee Chai, Suhn Young Im, Tai-You Ha, and Hern-Ku Lee (1998) Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J. Exp. Med., 188:(9)1587-1592
 
Suhn-Young Im,Jung-Hwa Choi, Hyun-Mi Ko, Su-Ji Han, Soon-Bai Chun, Hern-Ku Lee, Tai-You Ha (1997) A protective role of platelet-activating factor in murine candidiasis, Infec. Immun., 65(4):1321-1326
 
Nina F.L. Spencer, Matthew E. Poynter, Suhn-Young Im and Raymond A. Daynes (1997) Constitutive activation of NF-¥êB in an animal model of aging, Inter. Immunol. 9(10):1581-1588
 
Suhn-Young Im, Su-Ji Han, Hyun-Mi Ko, Jung-Hwa Choi, Soon-Bai Chun, Dong-Geun Lee, Tai-You Ha, Hern-Ku Lee (1997) Involvement of nuclear-¥êB in platelet-activating factor-mediated tumor necrosis factor-¥á expression, Eur. J. Immunol., 27:2800-2804
 
Suhn-Young Im, Hyun-Mi Ko, Yoo-Seung Ko, Jung-Woo Kim, Hern-Ku Lee, Tai-You Ha, Hwanghee Blaise Lee, Sang-Jim Oh, Suk Bai, Ki-Chul Chung, Young-Bo Lee. Hyun-Sam Kang, and Soon-Bai Chun (1996) Augmentation of tumor metastasis by platelet-activating factor. Cancer Research 56:2662-2665
 
Suhn-Young Im, Hyun-Mi Ko, Su-Ji Han, Jung-Hwa Choi, Chang-Soo Park, Hern-Ku Lee and Dong-Geun Lee (1996) Prevention of tumor growth and metastasis by interleukin (IL)-10 transfection : A potent inhibitory role of IL-10 on angiogenesis. Mol. Cells., 6:473-480