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Han, Ho-Jae
Title

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Associate Professor
Affiliation

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 Department Veterinary Physiology, College of Veterinary Medicine, Chonnam National University
Degree

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Ph.D. Seoul National University, Korea
Address

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 Department Veterinary Physiology, College of Veterinary Medicine, Chonnam National University 300 Yongbong-dong, Gwangj 500-757, Korea
Tel.

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+82-62-530-2831
FAX

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+82-62-530-2809
Email

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hjhan@chonnam.ac.kr

  

 

 

 

The most significant direct role of estrogen action in vivo is its ability to elicit receptor-mediated cellular proliferation in mammalian target tissues such as the uterus, vagina, and mammary gland. However, estrogens also documented physiological effects in a number of other target tissues, including kidney. However the mechanisms by which exogenously added estrogen cause the neoplastic transformation of renal cortical cells or alleviate postmenoposal osteoporosis is not understood, and the little is known regarding the role of estrogens in regulating the function of normal renal cortical cells. Also glucocorticoid excess causes a complex of hormonal effects called Cushing's disease. Alterations in the functional properties of renal proximal tubule epithelial cells have been attributed to superphysiological concentration of glucocorticoid. A primary cultured rabbit renal proximal tubule cells (PTC) in serum-free hormonally medium would be powerful tool for studying renal effects of steroid hormone. Recently our laboratory is interested in a) interaction between estrogen and growth factors on the proliferation and membrane transport functions, b) effects of glucocorticoid on renal transport functions and its action mechanism in PTC.

 

 

 

  1. Han Ho Jae, Soo Hyun Park, Kwon Moo Park, Byung Cheol Yoon, Tae Sung Kim, Jang Hern Lee. (2002) Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro. Planta Medica. (in press)
     
  2. Han Ho Jae, Soo Hyun Park, Park Kwon Moo, Byeong Cheol Yoon, Jang Hern Lee, Woong Chon Mar, Hye Jung Lee, Sung Keel Kang.(2002) Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells, Clinical and Experimental Physiology and Pharmacology. (in press)
     
  3. Kwon YB, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz AJ, Lee JH (2002) Water-soluble fraction of bee venom produced antinociceptive and anti-inflammatory effect on rheumatoid arthritis in rats. Life Sciences. (in press)
     
  4. Kim HW, Kwon YB, HamTW, Roh DH, Yoon SY, Han HJ, Kim KW, Lee WS, Kim JK, and Lee JH (2002) Distribution of Nociceptin-like Immunoreactivity in the Central Nervous System of the Mongolian Gerbil; an Immunohistochemical study. Anat. Histol. Embryol. (in press)
     
  5. Ho Jae Han, Yeune Hee Lee, Soo Huyn Park and Mary Taub (2002) Estradiol-17beta stimulates phosphate uptake and is mitogenic for primary rabbit renal proximal tubule cells. Experimental Nephrology. (in press)
     
  6. Soo Hyun Park, Chang Hoon Woo, Jae Hong Kim, Jang Hern Lee, Il Suk Yang, Ho Jae Han (2002) High glucose downregulates angiotensin II binding via PKC-MAPK-cPLA2 signal cascade in renal proximal tubule cells. Kidney International 61(3):913-925

  7. Ho Jae Han, Soo Hyun Park, Hyung Joo Park, Kwon Moo Park, Ju Won Kang, Jang Hern Lee, Byeong Chun Lee, Woo Suk Hwang (2002) Effect of various estrogens on cell injury and alteration of apical transporters induced by tert-butyl hydroperoxide in renal proximal tubule cells. Clinical and Experimental Physiology and Pharmacology 29(1-2):60-67
     
  8. Soo Hyun Park, Ho Jae Han (2002) Mechanism of angiotensin II binding downregulation by high glucose in primary cultured renal proximal tubule cells. American Journal of Physiology-Renal Physiology 282(2):F228-F237
     
  9. Ho Jae Han, Soo Hyun Park, Hyung Joo Park, Jang Hern Lee, Byeong Chun Lee, Woo Suk Hwang (2001) Effects of sex steroid hormones on Na+/glucose cotransporter of renal proximal tubular cells following oxidant injury. Kidney & Blood Press Res 24(3):159-165.  
     
  10. Young Bae Kwon, Ji Hoon Kim, Jung Hee Yoon, Jae Dong Lee, Ho Jae Han, Woung Chon Mar, Alvin J Beitz, Jang Hern Lee (2001) The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture. Am J Chinese Med. 29(2):187-199

  11. Young-Bae Kwon, Myung-Soo Kang, Ho-Jae Han, Alvin J. Beitz, Jang-Hern Lee (2001) Visceral Antinociception Produced By Bee Venom Stimulation of the Zhongwan Acupuncture Point In Mice: Role of  2 adrenoceptors. Neurosci. Lett. 308:133-137.
     
  12. Soo Hyun Park, Sung Shik Shin, Ho Jae Han (2001) High glucose alters angiotensin II-induced Ca2+ uptake via PKC and cAMP pathways in renal proximal tubule cells. Kidney & Blood Pressure Research. 24(2);84-91.
     
  13. Yong Bae Kwon, Myung Soo Kang, Hyun Woo Kim, Tae Won Ham, Yoon Kyung Yim, Sun Hee Jeong, Son Seok Park, Do Young Choi, Ho Jae Han, Alvin J Beitz, Jang Hern Lee (2001) Antinociceptive effects of bee venom acupuncture (Apipuncture) in rodent animal models: A comparative study of acupoint versus non-acupoint stimulation. Acupuncture & Electrotherapeutics Res. 26(1-2);59-68
     
  14. Soo Hyun Park, Hyun Ju Choi, Jang Hern Lee, Chang Hoon Woo, Jae Hong Kim, Ho Jae Han (2001) High glucose inhibits renal proximal tubule cell proliferation: Involvement of protein kinase C, oxidative stress, and transforming growth factor- 1. Kidney Int. 59(5);1695-1705
     
  15. Jang-Hern Lee, Young-Bae Kwon, Ho-Jae Han, Woung-Chon Mar, Hye-Jung Lee, Il-Suk Yang, Alvin J. Beitz, Sung-Keel Kang (2001). Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation. J Vet Med Sci. 63(3);251-259
     
  16. Young Bae Kwon, Jae Dong Lee, Hye Jung Lee, Ho Jae Han, Woo Chon Mar, Beitz AJ, Jang Hern Lee (2001) Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive response. Pain 90(3);271-280
     
  17. Soo Hyun Park, Hyun Ju Choi, Jang Hern Lee, Il Suk Yang, Ho Jae Han (2001) High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells. Kidney & Blood Pressure Research. 24(1);10-17
     
  18. Soo Hyun Park, Mary Taub, Ho Jae Han (2001) Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: Evidence for nongenomic as well as genomic mechanisms. Endocrinology 142(2);710-712
     
  19. Chang Hoon Woo, Young Woo Eom, Min Hyuk Yoo, Hae Jin You, Ho Jae Han, Woo Keun Song, Yung Joon Yoo, Jang Soo Chun, Jae Hong Kim (2000) Tumor necrosis factor-  generates reactive oxygen species via a cytosolic phospholipaseA2-linked cascade. J Biol Chem. 275:32357-32362
     
  20. Young Bae Kwon, Myung Soo Kang, Sung Sae Son, Jun Tae Kim, Yon Ho Lee, Ho Jae Han, Jang Hern Lee (2000) Different frequencies of electropuncture modified the cellular activity of serotonergic neurons in brainstem. Am J Chinese Med. 28(3-4):435-441
     
  21. Ho Jae Han, Jang Hern Lee, Soo Hyun Park, Hyun Joo Choi, Il Suk Yang, Woong Chon Mar, Sung Keel Kang, Hye Jung Lee (2000) Effect of bee venom and its mellitin on apical transporters of renal proximal tubule cells. Kidney & Blood Pressure Research.  23(6):393-396
     
  22. Young Bae Kwon, Myung Soo Kang, Chun Jae Ahn, Ho Jae Han, Byoung Choul Ahn, Jang Hern Lee (2000) Effect of high or low frequency electroacupuncture on the cellular activity of catecholaminergic neurons in the brain stem. Acupuncture & Electrotherapeutics Res, 25;27-36
  23. Ho Jae Han, Hyun Ju Choi, Soo Hyun Park (2000) High glucose-induced inhibition of α-methyl-D-glucopyranoside uptake is mediated by protein kinase C-dependent activation of arachidonic acid release in primary cultured rabbit renal proximal tubule cells. J Cell Physiol. 183:355-363
     
  24. Ho Jae Han, Hyun Ju Choi, Soo Hyun Park (2000) High glucose inhibits glucose uptake in renal proximal tubule cells by oxidative stress and protein kinase C. Kidney International. 57:918-926
  25. Ho Jae Han, Soo Hyun Park, Hyun Ju Kho, Mary Taub (2000) Mechanism of regulation of Na+ transport by angiotensin II in primary renal cells. Kidney International. 57(6):2457-2467
  26. Ho Jae Han, Yeune Hee Lee, Soo Hyun Park (2000) Estradiol-17β-BSA stimulates Ca2+ uptake through nongenomic pathways in primary rabbit kidney proximal tubule cells: Involvement of cAMP and PKC. J Cell Physiol. 183:37-44
     
  27. Young Bae Kwon, Il Suk Yang, Kyung Sun Kang, Ho Jae Han, Yong Soon Lee, Jang Hern Lee (2000) Effects of dizocilpine pretreatment on parvalbumin   immunoreactivity and Fos expression after cerebral ischemia in the hippocampus of the Monolian gerbil. J Vet Med Sci 62(2):141-146
     
  28. Jang Hern Lee, Hyun Woo Kim, Young Bae Kwon, Myung Soo Kang, Dong Won Choi, Jun Ho Na, Ho Jae Han and Myung Haing Cho (2000) General pharmacology studies on beta-domain deleted recombinant factor VIII. Arzneimittelforschung, 50(1):86-92
     
  29. Kyong Choi, Sung Wook Park, Kwang Jae Lee, Hwanghee Blaise Lee, Ho Jae Han, Sung Kwang Park, Haeng Soon Park (2000) Grass carp (ctenopharyngodon idellus) bile may inhibit the release of renal olipeptiolase from the proximal tubules by nitric oxide generation. Kidney & Blood Pressure Research. 23(2):113-118
     
  30. Ho Jae Han, Dae Hoon Kim, Soo Hyun Park (2000) Regulatory mechanism of Na/Pi cotransport by glucocorticoid in renal proximal tubule cells: Involvement of cAMP and PKC. Kidney & Blood Pressure Research 23:1-9
     
  31. Ho Jae Han, Dae Hoon Kim, Soo Hyun Park, Young Soon Lee, Jang Hern Lee, Il Suk Yang (1999) Regulatory mechanism of polarized membrane transport by glucocorticoid in renal proximal tubule cells: Involvement of [Ca2+]i. J Vet Med Sci 61(11); 1197-1202
     
  32. Young Bae Kwon, Yeo Sung Yoon, Ho Jae Han, Jang Hern Lee (1999) Effect of 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitor, on parvalbumin immunoreactivity after cerebral ischaemia in the hippocampus of the Mongolian gerbil. Anatomia Histologia Embryologia. 28:325-329
     
  33. Bok Yun Kang, Jeoung Soon We, Kyong Choi, Hwanghee Blaise Lee, Ho Jae Han, Haeng Soon Park (1999) Release of renal depeptidase from rabbit renal proximal tubules and its inhibition by gentamicin. Arch Pharm Res 22(4); 367-371
     
  34. Ho Jae Han, Yeun Hee Lee, Soo Hyun Park, Hyun Ju Choi, Chang Ho Son, Yong Dal Yoon (1999) Estradiol-17β stimulates Ca2+ uptake through nongenomic action in renal proximal tubule cells. Recent progress in molecular and comparative endocrinology. 515-521
     
  35. Ho Jae Han, Soo Hyun Park, Hyun Ju Koh, Seung Yeol Nah, Dong Ho Shin, Han Sun Choi (1999) Protopanaxatriol ginsenosides inhibit glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release. Kidney & Blood Pressure Research. 22(3):114-120
     
  36. Ho Jae Han, Soo Hyun Park, Jae Cheon Lee, Hwanghee Blasie Lee, Haeng Soon Park (1999) Leukotrien D4 inhibits Na+ uptake through cAMP and PLC pathways in the primary cultured renal proximal tubular cells. Kidney & Blood Pressure Research. 22(3) :106-113
     
  37. Ho Jae Han, Hyun Ju Koh, Soo Hyun Park (1999) A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells. J Vet Med Sci 61(2):135-141
     
  38. Ho Jae Han, Jee Chang Jung, Mary Taub (1999) Response of primary rabbit kidney proximal tubule cells to estrogens. J Cell Physiol. 178:35-43

 

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