Chun, Sang-Young
Title: Assistant Professor
Affiliation: Hormone Research Center, Chonnam National University
Degree:Ph.D. Weizmann Research Institute of Science, Rehovot, Israel
Address: Hormone Research Center, Chonnam National University, Kwangju,500-757
Tel.:+82-62-530-0502
FAX:+82-62-530-0500
Email:sychun@orion.chonnam.ac.kr

The main interest is to investigate the control mechanisms of ovarian follicle development in the rat. These include the initiation of primordial follicle activation, the formation of follicle antrum, and selection of dominant follicles. Current research topics include;

  • Hormonal regulation and physiological roles of pituitary adenylate cyclase activating polypeptide (PACAP), recently identified neuropeptide, in the rat ovary.
  • Gonadotropin regulation of phosphodiesterase (PDE) mRNAs in the rat ovary.
  • Regulation of cGMP levels in ovarian cells by nitric oxide and natriuretic peptide pathways.
  • Cloning of genes by Differential-Display PCR (DD-PCR) involved in the initiation of primordial follicle activation, antrum formation, and ovulation
  • Hormonal control of follicle apoptosis in the rat ovary.

  1. Park JY, Richard F, Chun SY, Park JH, Law E, Horner K, Jin SL, Conti M. (2003) Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle. Mol Endocrinol. Jun;17(6):1117-30.
     
  2. Park JI, Park HJ, Lee YI, Seo YM, Chun SY.(2003) Regulation of NGFI-B expression during the ovulatory process. Mol Cell Endocrinol.28;202(1-2):25-9.
     
  3. Yong Soo Lee, Hyun-Jin Kim, Hyun Ju Lee, Jae Woon Lee, Sang-Young Chun, Sun-Kun Ko, and Keesook Lee (2002) Activating Signal Cointegrator 1 Is Highly Expressed in Murine Testicular Leydig Cells and Enhances the Ligand-Dependent Transactivation of Androgen Receptor. Biol Reprod 67: 1580-1587.
     
  4. Kim MS, Hur MK, Son YJ, Park JI, Chun SY, D'Elia AV, Damante G, Cho S, Kim K, Lee BJ. (2002) Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J Biol Chem. 27;277(39):36863-71.
     
  5. Conti M, Andersen CB, Richard F, Mehats C, Chun SY, Horner K, Jin C, Tsafriri A.
    (2002)     Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol. 22;187(1-2):153-9.
     
  6. Chun SY, Bae HW, Kim WJ, Park JH, Hsu SY and Hsueh AJW (2001) Expression of messenger ribonucleic acid for the antiapoptosis gene P11 in the rat ovary : gonadotropin stimulation in granulosa cells of preovulatory follicles. Endocrinology, 142(6):2311~2317
     
  7. Park JI, Park HJ, Choi HS, Lee K, Lee WK, Chun SY (2001) Gonadotropin regulation of NGFI-B messenger RNA expression during ovarian follicle development in the rat. Endocrinology, 142(7):3051~3059
     
  8. Park JY, Park JH, Park HJ, Lee JY, Lee YI, Lee K and Chun SY (2001) Stage-dependent regulation of ovarian pituitary adenylate cyclase-activating polypeptide mRNA levels by GnRH in cultured rat granulosa cells. Endocrinology, 142(9):3828~3835
     
  9. Park H-J, Lee J, Wang L, Park J-H, Kwon H-B, Arimura A, Chun S-Y (2000) Stage-specific expression of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid during ovarian follicle development in the rat. Endocrinology 141:702-709
     
  10. Park J-I, Kim W-J, Park H-J, Wang L, Lee J, Park J-H, Kwon H-B, Tsafriri A, Chun S-Y (2000) Involvement of progesterone in gonadotrophin-induced pituitary adenylate cyclase-activating polypeptide gene expression in preovulatory follicles of rat ovary. Mol Human Reprod 6:238-245
     
  11. Koh PO, Kwak SD, Kang SS, Cho GJ, Chun S-Y, Kwon HB, Choi WS (2000) Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type IA receptor mRNAs in granulosa cells of preovulatory follicles of the rat ovary. Mol Reprod Dev 55:379-386
     
  12. Leo CP, Hsu S-Y, Chun S-Y, Bae H-W, Hsueh AJW (1999) Characterization of the antiapototic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Endocrinology 140:5469-5477
     
  13. Lee J, Park H-J, Choi H-S, Kwon H-B, Arimura A, Lee B-J, Choi W-S and Chun S-Y (1999) Gonadotropin stimulation of pituitary adenylate cyclase-activating polypeptide (PACAP) messenger ribonucleic acid in the rat ovary and the role of PACAP as a follicle survival factor. Endocrinology 140:818-826
     
  14. Chun S-Y, McGee EA, Hsu SY, Minami A, LaPolt PS, Yao H-C, Bahr JM, Gougeon A, Schomberg DW and Hsueh AJW (1999) Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. Biol Reprod 60:365-373
     
  15. McGee EA, Chun S-Y, Lai S, He Y and Hsueh AJW (1999) Keratinocyte growth factor promotes the survival, growth, and differentiation of preantral ovarian follicles. Fertil Steril 71:732-738
     
  16. Salanova M, Chun S-Y, Iona A, Puri C, Stefanini M and Conti M (1999) Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis. Endocrinology 140:2297-2306
     
  17. Chun S-Y and Hsueh AJW (1998) Paracrine mechanisms of ovarian follicle apoptosis. J Reprod Immunol, 39:63-75
     
  18. McGee E, Spears N, Minami S, Hsu S-Y, Chun S-Y, Billig H and Hsueh AJW (1997) Preantral ovarian follicles in serum-free culture: suppression of apoptosis after activation of the cyclic guanosine 3 ,5 -monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone. Endocrinology, 138:2417-2424
     
  19. Chun S-Y, Eisenhauer KM, Minami S, Billig H, Perlas E and Hsueh AJW (1996) Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor. Endocrinology, 137:1447-1456
     
  20. Hsueh AJW, Eisenhauer KM, Chun S-Y, Hsu SY and Billig H (1996) Gonadal cell apoptosis. Recent Prog Horm Res, 52:435-458
     
  21. Billig H, Chun S-Y, Eisenhauer KM and Hsueh AJW (1996) Gonadal cell apoptosis: hormone-regulated cell demise. Hum Reprod Update, 2:103-117
     
  22. Chun S-Y, Eisenhauer KM, Minami S and Hsueh AJW (1996) Growth factors in ovarian follicle atresia. Seminars Reprod Endocrinol, 14(3):197-202
     
  23. Nahum R, Beyth Y, Chun S-Y, Hsueh AJW and Tsafriri A (1996) Early onset of DNA fragmentation during atresia of preovulatory ovarian follicles. Biol Reprod, 55:1075-1080
     
  24. Kaipia A, Chun S-Y, Eisenhauer KM and Hsueh AJW (1996) Tumor necrosis factor-a and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology, 137:4864-4870
     
  25. Tsafriri A, Chun S-Y, Zhang R, Hsueh AJW and Conti M (1996) Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Dev Biol, 178:393-402
     
  26. Tsafriri A and Chun S-Y (1996) Ovulation. In:Adashi EY, Rock JA and Rosenwaks Z (eds.). Reproductive Endocrinology, Surgery and Technology. Lippncott-Raven Press, Philadelphia, Penn. Vol 1, pp235-249