Chae, Ho-Zoon
Title: Assistant Professor
Affiliation:Department of Biology, Chonnam National University
Degree:Ph.D. Yonsei University, Korea
Address:Department of Biology College of Natural Sciences Chonnam National University 300 Buk-ku, Yongbong-dong Kwangju, Korea 500-757
Tel.:+82-62-530-3398
FAX:+82-62-530-0500
Email:hzchae@orion.chonnam.ac.kr

1) Redox mediated control of signal transduction
  • Control mechanism of cell proliferation and differentiation depending on redox reaction : in vivo functional role of peroxiredoxin and thioredoxin on transiently induced ROS by the stimulation of growth factors, hormones, and cytokines
  • Screening of thioredoxin target molecules by using substrate trap mutants
2) Characterization and functional study of peroxiredoxins
  • Characterization and functional study of peroxiredoxins Peroxidase activities and their reaction mechanisms of peroxiredoxins : Enzymological study of 6 mammalian peroxiredoxin iso-types
  • Functional role of peroxiredoxins on oocyte maturation, cancer metastasis, and sepsis models

  1. Yang K.S., Kang S.W., Woo H.A., Hwang S.C., Chae H.Z., Kim K., Rhee S.G., Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of catalytic site cysteine to cys-sulfinic acid. J. Biol. Chem. (2002) 277, 38029-38036
     
  2. Lee J.B., Yun S.J., Chae H.Z., Won Y.H., Kim Y.P., Lee S.C., Expression of peroxiredoxin and thioredoxin in dermatological disorders. Br. J. Dermatol. (2002) 146, 710-712
     
  3. Koo K.H., Lee S., Jeong S.Y., Kim E.T., Kim H.J., Kim K., Song K., Chae H.Z., Regulation of thioredoxin peroxidase activity by C-terminal truncation. Arch. Biochem. Biophys. (2002) 397, 312-318
     
  4. Noh D.Y., Ahn S.J., Lee R.A., Kim S.W., Park I.A., Chae H.Z., Overexpression of peroxiredoxin in human breast cancer. Anticancer Res. (2001) 21, 2085-2090
     
  5. Lee S.P., Hwang Y.S., Kim Y.J., Kwon K.S., Kim H.J., Kim K., Chae H.Z., Cyclophilin a binds to peroxiredoxins and activates its peroxidase activity. J. Biol. Chem. (2001) 276, 29826-29832
     
  6. Jung H., Kim T., Chae H.Z., Kim K.T., Ha H., Regulation of macrophage migration inhibitory factor and thiol-specific antioxidant protein PAG by direct interaction. J Biol. Chem. (2001) 276, 15504-10.
     
  7. Park S.H., Chung Y.M., Lee Y.S., Kim H.J., Kim J.S., Chae H.Z. and Yoo Y.D., Antisense of human peroxiredoxin II enhances radiation-induced cell death. Clin Cancer Res. (2000) 6, 4915-4920
     
  8. Lee S.C., Chae H.Z., Lee J.E., Kwon B.D., Lee J.B., Won Y.H., Ahn K.Y. and Kim Y.P., Peroxiredoxin is ubiquitously expressed in rat skin: isotype-specific expression in the epidermis and hair follicle. J. Invest. Dermatol. (2000) 115, 1108-1114.
     
  9. Hwang Y.S., Chae, H.Z., and Kim K., Characterization of Haemophilus influenzae Peroxiredoxins. J. Biochem. Mol. Biol. (2000) 33, 514-518
     
  10. Lyu MS, Rhee SG, Chae HZ, Lee TH, Adamson MC, Kang SW, Jin DY, Jeang KT, Kozak CA (1999) Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences. Mamm. Genome 10: 1017-1019
     
  11. Chae, H. Z., Kim, H. J., Kang, S. W., and Rhee, S. G.(1999) Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin. Diabetes. Res. Clin. Prac. 45: 101-112
     
  12. Chae, H.Z., Kim, K., and Kim, I.-H. (1999) The Novel Antioxidant Enzyme, Thioredoxin Peroxidase, and Mammalian Peroxiredoxins. In: Packer, L., and Yodoi, J. (ed), Redox regulation of Cell signaling and Its Clinical Application. New York: Marcel Dekker, Inc., 85-92, ISBN: 0-8247-1961-1
     
  13. Chae H. Z., Peroxiredoxin: A novel family of antioxidant enzymes. Biochem. News (1999) 19, 260-269 
     
  14. Chae, H.Z., Kang, S.W. and Rhee, S.G. (1999) Isoforms of Mammalian Peroxiredoxin That Reduce Peroxides in Presence of Thioredoxin. Methods Enzymol. 300:219-226
     
  15. Kang, S.W., Chae, H.Z., Seo, M.S., Kim, K., Vains, I.C., and Rhee, S.G. (1998) Mammalian Peroxiredoxin Isoformes Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor ¥á. J. Biol. Chem. 273:6297-6302
     
  16. Lim, M.J., Chae, H.Z., Rhee, S.G., Yu, D.Y., Lee, K.K., and Yeom, Y.I. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216:197-205
     
  17. Jin, D.-Y., Chae, H.Z., Rhee, S.G., and Jeang, K.-T. (1997) Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-¥êB Activation. J. Biol. Chem. 272:30952-30961
     
  18. Poole, L.B., Chae, H.Z., Flores, B.M., Reed, S.L., Rhee, S.G., and Torian, B. (1997) Peroxidase activity of a TSA-like antioxidant protein from a pathogenic amoeba. Free Rad. Biol. Med. 23:955-959
     
  19. Netto, L.E.S., Chae, H.Z., Kang, S.W., Rhee, S.G., and Stadtman, E.R. (1996) Removal of Hydrogen Peroxide by Thiol-specific Antioxidant Enzyme (TSA) Is Involved with Its Antioxidant Properties. TSA POSSESSES THIOL PEROXIDASE ACTIVITY. J. Biol. Chem. 271:15315-15321
     
  20. Paula Pahl, Ralph Berger, Iris Hart, Ho Zoon Chae, Sue Goo Rhee, and David Patterson (1995) Localization of TDPX1, a Human Homologue of the Yeast Thioredoxin-Dependent Peroxide Reductase Gene (TPX), to chromosome 13q12, Genomics, 26:602-606
     
  21. Ho Zoon Chae, Sang Jin Chung, Sue Goo Rhee (1994) Thioredoxin-dependent peroxide reductase from yeast, J. Biol.Chem. 269:27670-27678
     
  22. S.G. Rhee, K.H. Kim, H.Z. Chae, M.B. Yim, K. Uchida, L.E.S. Netto, and E.R. Stadtman (1994) Antioxidant Defense Mechanisms; A Novel Thiol-Specific Antioxidant Enzymes, Annals New York Acad. Sci. 738:86-92
     
  23. Sue Goo Rhee and Ho Zoon Chae (1994) Mini-review on Thioredoxin peroxidase and peroxiredoxin family, Molecules and Cells, 4:137-142
     
  24. Ho Zoon Chae, Tae Bung Uhm, and Sue Goo Rhee (1994) Essential Cysteine-47 and dimerization of thiol-specific antioxidant, Proc. Natl. Acad. Sci. U.S.A. 91:7022-7026
     
  25. Ho Zoon Chae, Keith Robison, Leslie B. Poole, George Church, Gisela Storz, and Sue Goo Rhee (1994) Purification, cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes, Proc. Natl. Acad. Sci. U.S.A. 91:7017-7021
     
  26. Ho Zoon Chae, Sue Goo Rhee (1994) Thiol-specific antioxidant and sequence homology to various proteins of unknown function, BioFactors, 4:177-180
     
  27. Moon Bin Yim, Ho Zoon Chae, Sue Goo Rhee, P. Boon Chock and Earl R. Stadtman (1994) Thiyl Radicals, damaging species, and the Thiol Specific Antioxidant Enzymes, J. Biol. Chem. 269:1621-1626
     
  28. Ho Zoon Chae, Il Han Kim, Kanghwa Kim, and Sue Goo Rhee (1993) Cloning, Sequencing, and Mutation of Thiol-specific Antioxidant Gene of Saccharomyces cerevisiae, J. Biol. Chem. 268:16815-16821
     
  29. Koji Uchida, Luke I. Szweda, Ho Zoon Chae, and Earl R. Stadtman (1993) Immunochemical Detection of 4-Hydroxy-2-nonenal Protein Adducts in Oxidized Rat Hepatocytes, Proc. Natl. Acad. Sci. U.S.A. 90:8742-8746
     
  30. Stephen J. Taylor, Ho Zoon Chae, Sue Goo Rhee, John H. Exton (1991) Activation of b1 isozyme of phospholipase C by a subunits of the Gq class of G proteins, Nature 350:516-518
     
  31. Kim Y.S. and Chae H.Z. Purification and properties of Malonyl-CoA Synthetase from Rhizobium japonicum, Biochem. J. (1991) 273, 511-516.
     
  32. Kim Y.S. and Chae H.Z., A model of nitrogen flow by malonamate in Rhizobium japonicum-soybean symbiosys, Biochem. Biophys. Res. Comm. (1990) 169, 692-699.