Researchers

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Choi,
Hueng-Sik

Title

:

Associate Professor

Affiliation

:

Hormone Research Center, Chonnam National University

Degree

:

Ph.D. Rutgers University-The State University of New Jersey, USA

Post-Doc

:

Harvard Medical School

Address

:

Hormone Research Center, Chonnam National University,
Kwangju,500-757

Tel

:

+82-62-530-0503

Fax

:

+82-62-530-0500

Email

:

hsc@chonnam.ac.kr

 

  Research Interest


The nuclear hormone receptor superfamily is a group of transcription factors regulated by small hydrophobic hormones such as retinoic acid, thyroid hormone, and steroids and also includes a large number of related proteins that do not have known ligands, referred to as orphan nuclear receptors. Main research interest of my laboratory is to determine the role of orphan nuclear receptors in cell growth, differentiation and apoptosis. Currently, we are focusing our research on the mechanism of action of orphan nuclear receptor in reproductive system.

 

  Recent Publications

 
  1. Cheol Yi Hong, Jin Hee Park, Kook Heon Seo, Jin-Man Kim, Suhn Young Im, Jae Woon Lee, Hueng-Sik Choi and Keesook Lee (2003) Expression of MIS in the testis is downregulated by TNF-alpha through the negative regulation of SF-1 transactivation by NF-kappaB. Mol. Cell. Biol. 23(17):6000-6012.
     
  2. Sabyasachi Sanyal, Christoph Handschin, Michael Podvinec, Kwang-Hoon Song, Han-Jong Kim, Joon-Young Kim, Young-Woo Seo, Sung-A Kim, Hyuk-Bang Kwon, Keesook Lee, Won-Sun Kim, Urs A. Meyer and Hueng-Sik Choi. (2003) Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. Gen. Comp. Endocrinol. 132(3):474-84 
     
  3. Jae Young Seong, Li Wang, Da Young Oh, Oim Yun, Kaushik Maiti, Jian Hua Li, Jae Mok Soh, Hueng Sik Choi, Kyungjin Kim, Hubert Vaudry, and Hyuk Bang Kwon. (2003) Ala/Thr201 in Extracellular Loop 2 and Leu/Phe290 in Transmembrane Domain 6 of Type 1 Frog Gonadotropin-Releasing Hormone Receptor Confer Differential Ligand Sensitivity and Signal Transduction. Endocrinology 144:454-466.  
  4. Kwang-Hoon Song, Tae-Moon Kim, Han-Jong Kim, Jung Woo Kim, Hong-Hee Kim, Hyuk-Bang Kwon, Won Sun Kim, and Hueng-Sik Choi. (2003) Molecular cloning and characterization of a novel inhibitor of apoptosis protein from Xenopus laevis. Biochem.Biophys.Res.Com. 301:236-242 
     
  5. Song KH, Lee K., and Choi HS. (2002) Endocrine disruptor Bisphenol A induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cell. Endocrinology, 143(6):2208-2215
     
  6. Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD and Choi HS. (2002) FOR, a novel orphan nuclear receptor related to FXR. J.Biol.Chem. 277:17836-17844.
     
  7. Jung-Won Ju, Arun Bandyopadhyay, Wook-Bin Im, Jongkyung Chung, Hyuk Bang Kwon and Hueng-Sik Choi (2002) Involvement of Phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii. Gen.and Comp.Endocrinol. 126:213-220.
     
  8. Sabyasachi Sanyal, Joon-Young Kim, Han-Jong Kim, Jun Takeda, Yoon-Kwang Lee, David D Moore, and Hueng-Sik Choi (2002) Differential regulation of the orphan nuclear receptor Small Heterodimer Parnter (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J.Biol.Chem. 277:18:1739
     
  9. Kwang-Hoon Song, Jae-Il Park, Mi-Ock Lee, Jaemog Soh, Keesook Lee, and Hueng-Sik Choi (2001) Luteinizing hormone induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells. Endocrinology  142:5116
     
  10. Han CY, Kim JH, Kim YS, Lee SK, Jung DJ, Kim SW, Park SY, Kang H, Choi HS, Lee JW and Pak YK (2001) The orphan nuclear receptor SHP, as a novel coregulator of nuclear factor-kB in oxLDL-treated macrophage cell Raw 264.7 J Biol Chem, 276:33736-33740
     
  11. Park JI, Park HJ, Choi HS, Lee K, Lee WK, Chun SY (2001) Gonadotropin regulation of NGFI-B messenger RNA expression during ovarian follicle development in the rat. Endocrinology, 142(7):3051~3
     
  12. Wang L, Oh DY, Bogerd J, Choi HS, Ahn RS, Seong JY, Kwon HB (2001) Inhibitory activity of alternative splice variants of the bullfrog GnRH receptor-3 on wild-type receptor signaling. Endocrinology. 142(9):4015-4025
     
  13. Wang L, Bogerd J, Choi HS, Seong JY, Soh JM, Chun SY, Blomenrohr M, Troskie BE, Millar RP, Yu WH, McCann SM, Kwon HB (2001) Three distinct types of GnRH receptor characterized in the bullfrog. Proc Natl Acad Sci USA, 98(1):361-366
     
  14. Hidekazu Nishigori, Hideaki Tomura, Naoko Tonooka, Masao Kanamori, Shirou Yamada, Kimie Sho, Ituro Inoue, Nobuyuki Kikuchi, Kazumichi Onigata, Itaru Kojima, Tomoko Kohama, Kazuya Yamagata, Qin Yang, Yuji Mtsuzawa, Takashi Miki, Susumu Seino, Mi-Young Kim, Hueng-Sik Choi, Yoon-Kwang Lee, David D. Moore and Jun Takeda (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc. Natl. Acad. Sci. USA, 98:575
     
  15. Yoo MS, Kang HM, Choi HS, Kim JW, Troskie BE, Millar RP and Kwon HB (2000) Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin-releasing hormone([Trp8] GnRH) in frog brain. Mol. Cell. Endocrinol, 164:197
      
  16. J. Bandyopadhyay, A. Bandyopadhyay, H.-S. Choi, H. B. Kwon, and H. M. Kang (1999) Cloning and characterization of cDNA encoding Cdc2 kinase, a component of maturation promoting factor, in Rana dybowskii. Gen. Comp. Endocrinol. 117:313
      
  17. Hyun-Ho Lim, Byung-Jae Park, Hueng-Sik Choi, Chul-Seung Park, Soo Hyun Eom, Joohong Ahnn (1999) Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca2+-activated K+ channels. Gene, 240:35
     
  18. Yoon-Kwang Lee, Keith L. Parker, Hueng-Sik Choi and David D. Moore (1999) Activation of the promoter of the orphan nuclear receptor SHP by orphan receptors that bind DNA as monomer. J. Biol. Chem. 274:20869-20873
     
  19. Koh H., Jee, K., Lee, B., Kim, J., Kim, D., Yun, Y-H., Kim, J.W., Choi, H-S., and Chung, J. (1999) Cloning and Characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK), a novel nuclear target of Akt. Oncogene, 18:5115-5119
     
  20. Jin Lee, Hyun-Jeong Park, Hueng-Sik Choi, Hyuk-Bang Kwon, Akira Arimura, Byung-Ju Lee, Wan-Sung Choi, and Sang-Young Chun (1999) Gonadotropin Stimulation of Pituitary Adenylate Cyclase-Activationg Polypeptide (PACAP) Messgenger Ribonucleic Acid in the Rat Ovary and the Role of PACAP as a Follicle Survival Factor. Endocrinology, 140:818-826
     
  21. Hae-Kyung Lee, Myong-Sik Yoo, Hueng-Sik Choi, Hyuk-Bang Kwon, and Jaemok Soh (1999) Retinoic acid up-regulate steroidogenic acute regulatory protein gene. Molecular and Cellular Endocrinology, 148:1-10
     
  22. Soo-Kyung Lee, Hueng-Sik Choi, Mi-Ock Lee, and Jae Woon Lee (1998) Estrogen receptor, a common interaction partner for a subset of nuclear receptor, Molecular Endocrinology, 12:1184-1192
     
  23. Han-Jong Kim, Soo-Kyung Lee, Soon-Young Na, Hueng-Sik Choi, and Jae Woon Lee (1998) Molecular Cloning of xRSC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2. Molecular Endocrinology, 12:1038-1047
     
  24. Soon-Young Na, Soo-Kyung Lee, Su-Ji Han, Hueng-Sik Choi, Suhn-Young Im, and Jae Woon Lee (1998) SRC-1 interacts with the p50 subunit and coactivates the NFkB-mediated transactivations, Journal of Biological Chemistry, 273:10831-10834
     
  25. Soo-Kyoung Lee, Han-Jong Kim, Soon-Young Na, Tae Sung Kim, Hueng-Sik Choi, Suhn-Young Im, and Jae Woon Lee (1998) Steroid Receptor Coactivator-1 coactivates activating protein-1-mediated transactiations through interaction with the c-jun and c-fos subunits, Journal of Biological Chemistry, 273:16651-16654
     
  26. Soon-Young Na, Han-Jong Kim, Soo-Kyung Lee, Hueng-Sik Choi, Doe-Sun Na, Mi-Ock Lee, Mirra Chung, David D. Moore, and Jae Woon Lee (1998) IkBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccaride-treated cells, Journal of Biological Chemistry, 273:3212-3215
     
  27. Hye-Kyung Lee, Yoon-Kwang Lee, Sun-Hwa Park, Youn-Sook Kim, Seong-Hoe Park, Jae Woon Lee, Hyuk-Bang Kwon, Jaemog Soh, David D. Moore, and Hueng-Sik Choi (1998) Structure and Expression of the Orphan Nuclear Receptor SHP gene, Journal of Biological Chemistry, 273:14398-14402
     
  28. Jaya Bandyopadhyay, Arun Bandyopadhyay, Hae Mook Kang, Hyuk Bang Kwon, and Hueng-Sik Choi (1998) Requirement of protein kinase C pathway during progesterone-induced oocyte maturation in amphibian, Rana dybowskii, Korean Journal of Biological Sciences, 2:87-91
     
  29. Soo-Kyung Lee, Soon-Young Na, Han-Jong Kim, Jaemog Soh, Hueng-Sik Choi, and Jae Woon Lee (1998) Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor, Molecular Endocrinology, 12:325-332
     
  30. Arun Bandyopadhyay, Jaya Bandyopadhyay, Han-Ho Choi, Hueng-Sik Choi and Hyuk-Bang Kwon (1998) Plasma membrane mediated action of progesterone in Amphibian (Rana dybowskii) oocyte maturation. General and Comparative Endocrinology, 109:293-301
     
  31. D.D. Moore, M.I. Baes, and H-S. Choi (1998) CAR receptors and related molecules and methods. U.S.S.N. 081934388. (ƯÇã)
     
  32. Mi-Run Song, Su-Kyong Lee, Young-Woo Surh, Hueng-Sik Choi, Jaewoon Lee, and Mi-Ock Lee (1998) Functional interactions between estrogen receptor and retinoid receptors. Biochemical Journal, 336(Pt3):711-717
     
  33. Arun Bandyopadhyay, Jaya Bandyopadhyay, Jonkyeong Chung, Hueng-Sik Choi and Hyuk-Bang Kwon (1998) Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes. General and Comparative Endocrinology, 113:230-239
     
  34. Soon-Young Na, Hueng-Sik Choi, Jung Woo Kim, Doe Sun Na, and Jae Woon Lee (1998) Bcl3, an IkB protein, as a novel transcription coactivator of the retinoid X receptor. Journal of Biological Chemistry, 273:30933-30938
     
  35. Barry M.Forman, Iphigenia Tzameli, Hueng-Sik Choi, Jasmine Chen, Devendranath Simha, Wongi Seol, Ronald M. Evans and David D. Moore (1998) Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature, 395:612-615
     
  36. Hueng-Sik Choi, Mirra Chung, Iphigenia Tzameli, Devendranath Simha, Yoon-Kwang Lee, Wongi Seol, and David D. Moore (1997) Differential Transactivation by two isoforms of the orphan nuclear hormone receptor CAR, Journal of Biological Chemistry, 272:23565-23571
     
  37. Wongi Seol, Hueng-Sik Choi, and David D. Moore (1996) An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors, Science, 272:1336-1339
     
  38. Hueng-Sik Choi, Wongi Seol, and David D. Moore (1996) A component of the 26S proteasome binds an orphan member of the nuclear hormone receptor superfamily, Journal of Steroid Biochemistry and Molecular Biology, 56:23-30
     
  39. Jae-Woon Lee, Hueng-Sik Choi, Jeno Gyrus, Roger Brent, and David D. Moore (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor, Molecular Endocrinology,9:243
     
  40. Wongi Seol, Hueng-Sik Choi, and David D.Moore (1995) Isolation of proteins that interact with specifically with the retinoid X receptor: two novel orphan receptor, Molecular Endocrinology, 9:72
     
  41. Bruno Dumas, Heater P.Harding, Hueng-Sik Choi, Katrina Lehmann, Mirra Chung, Michell A. Lazar, and David D. Moore (1994) A new orphan member of the nuclear hormone receptor superfamily closely related to rev-erb, Molecular Endocrinology,8:996
     
  42. Myriam Baes, Tod Gulick, Hueng-Sik Choi, Maria Grazia Martinoli, and David Moore (1994) A new orphan receptor that constitutively activates retinoic acid response element, Molecular and Cellular Biology, 14:1544
     
  43. Hueng-Sik Choi and David D. Moore (1993) Induction of c-fos and c-jun gene expression by phenolic antioxidants, Molecular Endocrinology, 7:1596

 

 

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